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U937

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Cat.No.
CSC-C8227L
Description
The U-937 cell line was derived by Sundstrom and Nilsson in 1974 from malignant cells obtained from pleural effusion from a patient with histiocytic lymphoma; studies since 1979 have shown that U-937 cells can be induced to terminal monocytic differentiation by supernatants from human mixed lymphocyte cultures, by phorbol esters, by vitamin D3 by gamma interferon, by tumor necrosis factor (TNF) and by retinoic acid; the cells are negative for immunoglobulin production and Epstein-Barr virus expression.

Receptor Expression: complement (C3)
Genes Expressed: lysozyme; beta-2-microglobulin (beta 2 microglobulin); tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-alpha, TNF alpha), after stimulation with phorbol myristic acid (PMA)
Products: lysozyme; beta-2-microglobulin (beta 2 microglobulin); tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-alpha, TNF alpha), after stimulation with phorbol myristic acid (PMA)

Tissue of Origin
Lung
Organism
Homo sapiens, human
STR DNA Profile
Amelogenin: X,X
CSF1PO: 12
D13S317: 10,12
D16S539: 12
D5S818: 12
D7S820: 9,11
THO1: 6,9.3
TPOX: 8,11
vWA: 14,15
D3S1358: 16
D21S11: 27,29
D18S51: 13,14
Penta E: 13
Penta D: 12,13
D8S1179: 12,13
FGA: 22,25
Source
Lymphoma, histiocytic
Culture Properties
Suspension
Morphology
monocyte
Recommended Medium
90% RPMI-1640 and 10% h.i. FBS
Quality Control
Mycoplasma specific PCR: negative; Bacteria specific PCR: negative
Storage and Shipping
liquid nitrogen vapor phase
Disease
histiocytic lymphoma
Application
This cell line is suitable as a transfection host.
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon.
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