This is one of a number of cell lines derived from malignant gliomas, e.g. U-87-MG, U-118-MG and U-373-MG isolated by J. Ponten and associates from 1966 to 1969. It differs from U-87-MG in morphology and it has a slower proliferation rate. U-138-MG shows strong similarity to U-118-MG, sharing at least six derivative marker chromosomes.
Homo sapiens ,human
STR DNA Profile
Penta E: 7
Penta D: 9,13
Hyperdiploid to pentaploid with several markers; the stemline chromosome number is near triploid with the 2S component occurring at 9.8%. Five markers [t(11;5), t(8q;4), t(19;?18), M1 and M2] were common to most S metaphases. One chromosome 4 could be found in every S metaphase. Chromosome composition was very uniform among cells.
DMEM supplemented with 4.5g/L glucose, 2mM glutamine and 10% h.i.FBS
or SuperCult® U-138 MG medium
Mycoplasma: negative in DAPI, microbiological culture, RNA hybridization, PCR assays
Immunology: cytokeratin -, desmin -, endothel -, GFAP -, neurofilament -, vimentin +
Viruses: ELISA: reverse transcriptase negative; PCR: EBV -, HBV -, HCV -, HHV-8 -, HI
Storage and Shipping
Frozen with 70% medium, 20% FBS, 10% DMSO at about 2 x 10^6 cells/ampoule; ship in dry ice; store in liquid nitrogen
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