Internucleosomal DNA fragmentation is a hallmark of Apoptosis in mammalian cells. Creative Bioarray's SuperDirect® DNA Fragmentation Assay Kit provides complete components including positive and negative control cells for conveniently detecting DNA fragmentation by fluorescence microscopy or flow cytometry. The TUNEL-based detection kit utilizes terminal deoxynucleotidyl transferase (TdT) to catalyze incorporation of fluorescein-12-dUTPAt the free 3'-hydroxyl ends of the fragmented DNA. The fluorescein-labeled DNA can then be observed by fluorescence microscopy orAnalyzed by flow cytometry.
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