Established from a 10-year-old boy with acute monocytic leukemia (AML FAB M5) at diagnosis; cells were described to carry a t(4;11); we found that MV4-11 carries an FLT3 internal tandem duplication; patented cell line. Both granulocyte colony stimulating factor (G-CSF) and granulocyte- macrophage colony stimulating factor (GM-CSF) support the short term and long term growth of MV4-11 cells and act synergistically to stimulate growth of the cells. The cells are dependent upon GM-CSF for long term growth.
Homo sapiens (human)
STR DNA Profile
Penta E: 7,18
Penta D: 9,10
48, XY, t(4;11)(q21;q23), +8, +19
medium supplemented with 2 mM L-glutamine, and 10% fetal bovine serum.
Fluorescence (DAPI) test: negative; Mycoplasma specific PCR: negative; Bacteria
specific PCR: negative
Storage and Shipping
Frozen with 70% medium, 20% FBS, 10% DMSO at about 2.5 x 10^6 cells/ampoule; ship in dry ice; store in liquid nitrogen
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