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MCF-7

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Cat.No.
CSC-C0262
Description
The MCF-7 cell line was established from the pleural effusion of a patient suffering from a breast adenocarcinoma. It retains several characteristics of differentiated mammary epithelium including the ability to process estradiol via cytoplasmic estrogen receptors and the capability of forming domes. Growth of MCF-7 cells is inhibited by tumor necrosis factor alpha (TNF alpha). Secretion of IGFBP's can be modulated by treatment with anti-estrogens.
Tissue of Origin
Breast
Organism
Homo sapiens, human
STR DNA Profile
Amelogenin: X,X
CSF1PO: 10
D13S317: 11
D16S539: 11
D5S818: 12
D7S820: 8,9
THO1: 6
TPOX: 9,12
vWA: 14,15
D3S1358: 16
D21S11: 30
D18S51: 14
Penta E: 7,12
Penta D: 12
D8S1179: 10,14
FGA: 23,25
Culture Properties
Adherent
Karyotype
The stemline chromosome numbers ranged from hypertriploidy to hypotetraploidy, with the 2S component occurring at 1%. There were 29 to 34 marker chromosomes per S metaphase; 24 to 28 markers occurred in at least 30% of cells, and generally one large submetacentric (M1) and 3 large subtelocentric (M2, M3, and M4) markers were recognizable in over 80% of metaphases. No DM were detected. Chromosome 20 was nullisomic and X was disomic.
Source
Breast
Morphology
epithelial-like
Recommended Medium
90% EMEM + 10% h.i. FBS
Quality Control
Tests for mycoplasma, bacteria and fungi were negative
Storage and Shipping
liquid nitrogen vapor phase
Application
The MCF-7 OS cell line can be used as a suitable transfection host.
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon.

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