This cell line was isolated from a liver biopsy of a male Caucasian aged 15 years, with a well differentiated hepatocellular carcinoma. The cells secrete a variety of major plasma proteins e.g. albumin, alpha2-macroglobulin, alpha 1-antitrypsin, transferrin and plasminogen. The cells demonstrate decreased expression of apoA-I mRNA and increased expression of catalase mRNA in response to gramoxone (oxidative stress). There is no evidence of a Hepatitis B virus genome in this cell line.
Homo sapiens, human
STR DNA Profile
modal number = 55 (range = 50 to 60); has a rearranged chromosome 1
Tests for mycoplasma, bacteria and fungi were negative
Storage and Shipping
liquid nitrogen vapor phase
The Hep-G2 cell line can be used for hepatocyte function study and specific protein expression, it also can be used as a suitable transfection host.
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