Established from the malignant ascitic effusion from a woman with metastatic breast carcinoma; described as being estrogen receptor-negative and progesterone receptor-positive
Human hypotriploid karyotype with 4% polyploidy - 62(55-64)<3n>XXX, +1, -2, -5, -5, +6, -8, -9, -10, -13, -13, -14, -15, -16, -17, -18, -20, -22, +6-8mar, add(X)(p11), der(X)t(X;9)(q21;q11), add(1)(p1?1), der(1)del(1)(p36)dup(1)(q22q32), del(1)(q11), der(
adherent epitheloid cells growing in monolayers
Mycoplasma: contamination was eliminated with Ciprobay (ciprofloxacin), then negative in DAPI, microbiological culture, RNA hybridization, PCR assays
Immunology: cytokeratin +, cytokeratin-7 +, cytokeratin-8 +, cytokeratin-17, cytokeratin-18 +, cytokerati
Storage and Shipping
Frozen with 70% medium, 20% FBS, 10% DMSO at about 2 x 10^6 cells/ampoule; ship in dry ice; store in liquid nitrogen
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XIAP over-expression is an independent poor prognostic marker in Middle Eastern breast cancer and can be targeted to induce efficient apoptosis
Authors: Hussain A R, Siraj A K, Ahmed M, et al.
The BMC cancer, 2017, 17(1): 640.
Gene signature to predict homologous recombination (hr) deficient cancer: U.S. Patent Application 14/772,549[P].
Authors: Lin C J, Peng G, Lin S Y, et al.
The U.S. Patent Application
Genome-wide transcriptome profiling of homologous recombination DNA repair
Authors: Peng G, Lin C C J, Mo W, et al.
The Nature communications. 2014, 5: 3361.