MTPN is an ankyrin repeat protein, that stimulates protein synthesis and cardiomyocyte growth to commence cardiac hypertrophy by activating the NF-kappaB signaling cascade. Myotrophin participates in cerebellar morphogenesis and takes part in differentiation of cerebellar neurons, particularly of granule cells. High levels of MTPN are expressed in human dilated cardiomyopathic and ischemic hearts. Recombinant human MTPN produced in E. coli is a single, non-glycosylated polypeptide chain of 138 amino acids (1-118 a.a.) and a molecular mass of 15 kDa. The MTPN is fused to a 20 amino acid His-Tag at the N-terminus and purified by proprietary chromatographic techniques.
Human MTPN expressed in E.coli
CAT# CSC-CTK0469-20 (20 μg); CAT# CSC-CTK0469-100 (100 μg)
Greater than 90% as determined by SDS-PAGE analysis.
Less than 1 EU/μg.
Protein solution containing 20 mM Tris-HCl (pH 8.0) and 10% glycerol.
Please centrifuge product briefly before opening vial. The dissolved protein can be diluted into other aqueous buffers and stored at -20°C for future use.
Storage & Stability
Store at 4°C if entire vial will be used within 1 week. Store frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
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