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ActoFactor™ Recombinant Human Matrix metallopeptidase 2 (HEK)
- Specification
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Cat.No.
CSC-CTK0369
Description
Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up- regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-2 is a secreted collagenase with specificity toward Type IV, V, VII, and X collagens. Recombinant human MMP-2 produced in HEK293 cells is a proform of the Human MMP-2 (Ala30-Cys660) and fused with a ployhistide tag at the C-terminus, having a MW of 71kDa.
Species
Human
Product Overview
Human MMP2 expressed in HEK cells
Molecular Mass
71 kDa
Size
CAT# CSC-CTK0369-10 (10 μg); CAT# CSC-CTK0369-50 (50 μg)
Expression System
HEK cells
Purity
Greater than 95% as determined by SDS-PAGE.
Activity
The activity was measured by its ability to cleave the colorimetric peptide substrate Mca-PLGL- DpaAR-NH2. The specific activity is > 1,000 pmoles/min/μg.
Endotoxin Level
Less than 1 EU/μg.
Formulation
The MMP-2 is supplied as a 0.2μm filtered solution in Tris, NaCl and Brij35.
Reconstitution
Please centrifuge product briefly before opening vial. The protein solution can be diluted into other aqueous buffers and stored at -20°C for future use.
Storage & Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. Can also be used as standard in Western blot, etc.
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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