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ActoFactor™ Recombinant Human Leptin (Anti-Obesity Protein)

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Cat.No.
CSC-CTK0606
Description
Leptin inhibits food intake and stimulates energy expenditure. Leptin also has thermogenic actions and regulates enzymes of the fatty acid oxidation. Severe hereditary obesity in rodents and humans is caused by defects in leptin production. In addition to its critical role in the physiological regulation of body weight, leptin has a variety of other physiological and pathological functions resembling those of cytokines. These functions include the regulation of hematopoiesis, angiogenesis, wound healing, inflammation and immune responses. Recombinant human Leptin produced in E. coli is a single, non-glycosylated polypeptide chain of 147 amino acids and a molecular mass of 16,240 Dalton.
Species
Human
Product Overview
Human LEP expressed in E.coli
Molecular Mass
16.24 kDa
Size
CAT# CSC-CTK0606-1 (1 mg); CAT# CSC-CTK0606-5 (5 mg)
Expression System
E.coli
Purity
Greater than 95% as determined by SDS-PAGE, FPLC and RP-HPLC analysis.
Activity
Recombinant human Leptin is fully biologically active when compared to standards. Biological activity was determined by inducing proliferation of BaF3 cells stably transfected with the long form of human leptin receptor.
Endotoxin Level
Less than 1 EU/μg.
Formulation
Sterile-filtered, white, lyophilized (freeze-dried) powder. Lyophilized from a concentrated (1 mg/ml), sterile solution with 0.0045 mM NaHCO3.
Reconstitution
Please centrifuge product briefly before opening vial. The lyophilized protein should be reconstituted in sterile, ultra-pure water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.
Storage & Stability
The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted rHu Leptin should be used immediately or stored long-term in undiluted working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon.
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