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ActoFactor™ Recombinant Human Interleukin 4 receptor

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Cat.No.
CSC-CTK0225
Description
IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain. The type I receptor contains in addition to the gamma chain an IL-4R alpha subunit, whereas the type II receptor contains the IL-13R alpha. The secreted extracellular domain of IL- 4R alpha, called sIL-4R alpha, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naive CD4+ T cells and class switching to IgG1 and IgE. Recombinant human sIL-4R alpha is a 207 amino acid protein which corresponds to the entire extracellular domain of IL-4R alpha.
Species
Human
Product Overview
Human IL4R expressed in HEK293 cells
Molecular Mass
23.7 kDa
Size
CAT# CSC-CTK0225-15 (15 μg); CAT# CSC-CTK0225-75 (75 μg)
Expression System
HEK293 cells
Purity
Greater than 97% as determined by SDS-PAGE and HPLC analysis.
Activity
The ED50 was determined by its ability to inhibit the IL-4 dependent proliferation of human TF-1 cells and is 2 x 10^5 units/mg.
Endotoxin Level
Less than 1 EU/μg.
Formulation
Recombinant human sIL-4 Receptor was lyophilized from a sterile-filtered solution with no additives.
Reconstitution
Please centrifuge product before briefly opening vial. The lyophilized protein should be reconstituted in sterile, ultra-pure water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.
Storage & Stability
The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted rHu sIL-4 Receptor should be used immediately or stored long-term in undiluted working aliquots at -20°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon.
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