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• To conduct a preclinical evaluation of the ability of natural killer cells to cytolyze bladder cancer cells that were modified to show enhanced expression of natural-killer group 2, member D (NKG2D) ligands by R8-liposome-bacillus Calmette-Guéin (BCG)-cell wall skeleton (CWS) treatment.
Angiogenesis is essential for tumor growth and progression. It has been demonstrated that the expression of angiogenesis stimulators (e.g. basic fibroblast growth factor and vascular endothelial growth factor) correlates to tumor progression in various human tumor types. Furthermore, endogenous angiogenesis inhibitors (e. Read more >
In the present study, we examined the antitumor activity of a series of trichlorobenzene-substituted azaaryl compounds and identified MPT0L145 as a novel FGFR inhibitor with better selectivity for FGFR1, 2 and 3. It was preferentially effective in FGFR-activated cancer cells, including bladder cancer cell lines expressing FGFR3-TACC3 fusion proteins (RT-112, RT-4). Read more >
Invasive bladder cancer has high morbidity and nearly uniform mortality when metastatic, with no therapeutic improvement in many years. Although chemotherapy combined with Chk1 inhibition has been investigated in several cancer types in which TP53 mutation is seen, this combination treatment approach has not been studied in bladder cancer. Read more >
Nephrotoxicity is the major dose-limiting adverse effect of cisplatin (CisPt) and results from CisPt-induced damage of tubular cells. Nephroprotective strategies are preferential to improve supportive care in cancer. We investigated a subset of purified substances originating from various plants or from marine sponges as to their potency to protect rat renal tubular cells (NRK-52E) against the cytotoxic and genotoxic effects of cisplatin. Read more >
We developed and validated an electrophysiological method for standardized preclinical assessment of the invasive potential of urothelial carcinoma of the bladder.
We have investigated the cytotoxicity and specific effects of selenite in human bladder cancer cell line RT-112 and its clonogenic variant RT-112 HB. Selenite inhibited cell growth and proliferation in both cell lines. Treated cells developed extensive vacuolization which was dose independent but occurring in differing time frames. Read more >
We investigated the effectiveness of ultrasound-mediated destruction of bubble liposome (UBL) for siRNA transfer by observing reduction in the luciferase activity of human bladder tumor RT-112 cells transfected with the luciferase gene (RT-112Luc) following luciferase siRNA transfer into the cells.
|Cat#||Product Name||Description||Recommended Medium||Price|
|CSC-C0334||BT-B||These cells were thought to be "stablished fr...||90% RPMI-1640 + 10% h.i. FBS||INQUIRY|
|CSC-C0335||SBC-2||These cells were thought to be "established f...||90% RPMI-1640 + 10% h.i. FBS||INQUIRY|
|CSC-C0336||SBC-7||These cells were thought to be "established f...||90% RPMI-1640 + 10% h.i. FBS + 2 mM L-glutami...||INQUIRY|
|CSC-C0387||ECV-304||DNA profiling studies revealed that STR patte...||Medium 199 supplemented with L-glutamine and ...||INQUIRY|
|CSC-C0413||BFTC-905||Established from a 51-year-old Chinese woman ...||80-90% DMEM + 10-20% h.i. FBS||INQUIRY|
|CSC-C0424||T24;T-24||Established from the primary tumor of an 81-y...||DMEM:Ham's F12 medium (1:1 mixture) supplemen...||INQUIRY|
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