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Although long-standing colonic inflammation due to refractory inflammatory bowel disease (IBD) promotes the development of colitis-associated cancer (CAC), the molecular mechanisms accounting for the development of CAC remains largely unknown. In this study, we investigated the role of gankyrin in the development of CAC since gankyrin is overexpressed in sporadic colorectal cancers. Read more >
Cell therapy offers the potential to treat gastrointestinal motility disorders caused by diseased or absent enteric neurons. We examined whether neurons generated from transplanted enteric neural cells provide a functional innervation of bowel smooth muscle in mice.
Enteric neural stem/progenitor cells (ENSCs) offer an innovative approach to treating Hirschsprung disease (HSCR) and other enteric neuropathies. However, postnatal-derived human ENSCs have not been thoroughly characterized and their behavior in the embryonic and postnatal intestinal environment is unknown.
Inflammatory bowel disease (IBD) is a severe inflammatory condition in the colon. To date, clinical solutions for this disease have been limited. Mesenchymal stem cells (MSCs), multipotential cells with immune regulation and anti-inflammatory functions, have been applied to treatment of IBD. However, the therapeutic effectiveness of MSCs still needs to be improved. Read more >
Orphan GPCRs provide an opportunity to identify potential pharmacological targets, yet their expression patterns and physiological functions remain challenging to elucidate. Here, we have used a genetically engineered knockin reporter mouse to map the expression pattern of the Gpr182 during development and adulthood. Read more >
Regulatory T cells (Tregs) are critical for self-tolerance. Although adoptive transfer of expanded Tregs limits graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation (HSCT), ex vivo generation of large numbers of functional Tregs remains difficult. Here, we demonstrate that in vivo targeting of the TNF superfamily receptor TNFRSF25 using the TL1A-Ig fusion protein, along with IL-2, resulted in transient but massive Treg expansion in donor mice, which peaked within days and was nontoxic. Read more >
Therapeutic strategies based on a specific oncogenic target are better justified when elimination of that particular oncogene reduces tumorigenesis in a model organism. One such oncogene, Musashi-1 (Msi-1), regulates translation of target mRNAs and is implicated in promoting tumorigenesis in the colon and other tissues. Read more >
To investigate the role of human umbilical cord mesenchymal stem cells (hucMSCs) in the treatment of dextran sulfate sodium (DSS)-induced inflammatory bowel disease (IBD).
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|CSC-7686W||adult stem cells||Bioarray, a pioneer in the adult stem cell fi...||-----||INQUIRY|
|CSC-7695W||Human Vertebral Mesenchymal Stem Cells (HVMSC)||Mesenchymal stem cells (MSC) are well-charact...||-----||INQUIRY|
|CSC-7700W||Human Umbilical Mesenchymal Stem Cells (HUMSC)||Mesenchymal stem cells (MSC) are a well-chara...||-----||INQUIRY|
|CSC-7725W||Human Pulmonary Mesenchymal Stem Cells (HPMSC)||Mesenchymal stem cells (MSC) are a well-chara...||-----||INQUIRY|
|CSC-7755W||Human Mesenchymal Stem Cells-hepatic (HMSC-he)||Mesenchymal stem cells (MSC) are well-charact...||-----||INQUIRY|
|CSC-7756W||Human Mesenchymal Stem Cells-bone marrow (HMSC-bm)||Mesenchymal stem cells (MSC) are well-charact...||-----||INQUIRY|
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