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  • Cat.No.
  • CSC-C0262
  • Tissue of Origin
  • Breast
  • Description
  • The MCF-7 cell line was established from the pleural effusion of a patient suffering from a breast adenocarcinoma. It retains several characteristics of differentiated mammary epithelium including the ability to process estradiol via cytoplasmic estrogen receptors and the capability of forming domes. Growth of MCF-7 cells is inhibited by tumor necrosis factor alpha (TNF alpha). Secretion of IGFBP's can be modulated by treatment with anti-estrogens.
  • Recommended Medium
  • EMEM supplemented with 2mM L-glutamine, sodium pyruvate, NEAA and 10 % FBS.
  • Organism
  • Homo sapiens, human
  • Morphology
  • epithelial-like
  • STR DNA Profile
  • Amelogenin: X,X
    CSF1PO: 10
    D13S317: 11
    D16S539: 11
    D5S818: 12
    D7S820: 8,9
    THO1: 6
    TPOX: 9,12
    vWA: 14,15
    D3S1358: 16
    D21S11: 30
    D18S51: 14
    Penta E: 7,12
    Penta D: 12
    D8S1179: 10,14
    FGA: 23,25
  • Culture Properties
  • Adherent
  • Karyotype
  • The stemline chromosome numbers ranged from hypertriploidy to hypotetraploidy, with the 2S component occurring at 1%. There were 29 to 34 marker chromosomes per S metaphase; 24 to 28 markers occurred in at least 30% of cells, and generally one large submetacentric (M1) and 3 large subtelocentric (M2, M3, and M4) markers were recognizable in over 80% of metaphases. No DM were detected. Chromosome 20 was nullisomic and X was disomic.
  • Source
  • Breast
  • Quality Control
  • Tests for mycoplasma, bacteria and fungi were negative
  • Storage and Shipping
  • liquid nitrogen vapor phase
  • Tissue
  • Breast
  • Application
  • The MCF-7 OS cell line can be used as a suitable transfection host.


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