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Agents capable of increasing radioiodine concentration by stimulating the sodium/iodide symporter (NIS) expression have been extensively investigated for the treatment of certain well-differentiated breast cancers.
Kisspeptins are peptides derived from the metastasis suppressor gene KISS1interacting with GPR54 as their corresponding receptor. The KISS1/GPR54 systemis one regulator of cellular motility mechanisms leading to decreased migrationand invasion. Its role in cell proliferation processes is not clearly understood. Read more >
Lobaplatin as a single agent and in combination with tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is investigated in in-vitro models of p53-negative triple-negative breast cancers (TNBCs) and compared with a model of oestrogen receptor-positive p53-positive breast cancer. In addition, the induction of programmed cell death by lobaplatin is further explored. Read more >
MicroRNAs (miRNAs), small non-coding RNAs, regulate fundamental cellular and developmental processes such as cell growth, apoptosis, migration, and invasion. In our present study, we investigated the inhibitory role of miR-145 on breast cancer cell migration as well as its underlying mechanism. Wound healing assay and transwell migration assay showed that ectopic expression of miR-145 significantly inhibited breast cancer cell migration. Read more >
Novel chelated metal complexes were synthesized from carbohydrazones to thiocarbohydrazones using metal-based drug designing platforms and their combination effect with Pb, a naphthaquinone were analyzed for anticancer activity in breast cancer cell lines. A panel of BRCA1 wild-type and mutated breast cancer cells: MCF-7 (BRCA1+ /ER+ ), MDA-MB-231 (BRCA1+ /ERα- ), HCC-1937 (BRCA1- /ERα- ), HCC1937/wt BRCA1, MX1 (BRCA1- /ERα- ), and MDA-MB-436 (BRCA1- /ERα- ) were screened for anti-cancer activity. Read more >
Tamoxifen, a selective estrogen receptor (ER) modulator, may affect cancer cell survival through mechanisms other than ER antagonism. In the present study, we tested the efficacy of tamoxifen in a panel of ER-negative breast cancer cell lines and examined the drug mechanism.
The identification of various biomolecules in cancer progression and therapy has led to the exploration of the roles of two cardinal players, namely Nitric Oxide (NO) and Reactive Oxygen Species (ROS) in cancer. Both ROS and NO display bimodal fashions of functional activity in a concentration dependent manner, by inducing either pro- or anti- tumorigenic signals. Read more >
We tested the efficacy of lapatinib, a dual tyrosine kinase inhibitor which interrupts the HER2 and epidermal growth factor receptor (EGFR) pathways, in a panel of triple-negative breast cancer (TNBC) cells, and examined the drug mechanism. Lapatinib showed an anti-proliferative effect in HCC 1937, MDA-MB-468, and MDA-MB-231 cell lines. Read more >
|Cat#||Product Name||Description||Recommended Medium||Price|
|CSC-6288W||MCF7-382||Species: human, Caucasian female 69 years old...||MEM + 10% FBS + 2mM L-Glutamine||INQUIRY|
|CSC-6289W||MCF7-422||Species: human, Caucasian female 69 years old...||MEM + 10% FBS + 2mM L-Glutamine||INQUIRY|
|CSC-6290W||MCF7-432||Species: human, Caucasian female 69 years old...||MEM + 10% FBS + 2mM L-Glutamine||INQUIRY|
|CSC-6291W||MCF7-488X1||Species: human, Caucasian female 69 years old...||MEM + 10% FBS + 2mM L-Glutamine||INQUIRY|
|CSC-6292W||MCF7-490X1||Species: human, Caucasian female 69 years old...||MEM + 10% FBS + 2mM L-Glutamine||INQUIRY|
|CSC-6293W||MCF7-492X1||Species: human, Caucasian female 69 years old...||MEM + 10% FBS + 2mM L-Glutamine||INQUIRY|
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