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ActoFactor™ Recombinant Mouse Interleukin 17E (IL-25, SF20)

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  • Specification
  • Recommended Products
  • Cat.No.
  • CSC-CTK0695
  • Description
  • IL-17E (also called IL-25) has a sequence similarity with IL17. It induces NF-kappaB activation, and stimulates the production of IL-8. IL-17E and IL-17B are ligands for the cytokine receptor IL- 17BR. IL-17E is a proinflammatory cytokine favoring Th2-type immune response. The upregulation of costimulation-induced IL-17E receptors and release of cytokines and chemokines from IL-17E treated costimulated Th cells are differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB activity. Blocking IL-17E prevents airway hyperresponsiveness, a critical feature of clinical asthma. IL-17E produced by innate effector eosinophils and basophils increase the allergic inflammation by enhancing the maintenance and functions of TSLP-DC activated adaptive Th2 memory cells. Over expression of IL-17E up-regulates gene expression of Th2 cytokines and induces growth retardation, jaundice, and multiorgan inflammation in a transgenic mouse model. IL-17E contributes to the induction and maintenance of eosinophilic inflammation by acting on lung fibroblasts which supports the fact that IL-17E is an important factor in asthma pathophysiology. IL-17E operates by amplifying TH2 cell-mediated allergic airway inflammation but doesn't induce allergic inflammation in vivo. Mouse recombinant IL-17E produced in E. coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 306 amino acids and having a molecular mass of 34.9 kDa.
  • Species
  • Mouse
  • Product Overview
  • Mouse Il25 expressed in E.coli
  • Molecular Mass
  • 34.9 kDa
  • Size
  • CAT# CSC-CTK0695-25 (25 μg); CAT# CSC-CTK0695-125 (125 μg)
  • Expression System
  • E.coli
  • Purity
  • Greater than 95% as determined by SDS-PAGE and RP-HPLC analysis.
  • Activity
  • N/A
  • Endotoxin Level
  • N/A
  • Formulation
  • Sterile-filtered, white, lyophilized (freeze-dried) powder. Lyophilized from a concentrated (1 mg/ml) protein solution containing no additives.
  • Reconstitution
  • Please centrifuge product briefly before opening vial. The lyophilized protein should be reconstituted in sterile, ultra-pure water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.
  • Storage & Stability
  • The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted protein should be used immediately or stored long-term in undiluted working aliquots at -20°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.

Citation Guidance:
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon.

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      Tel: 1-631-626-9181
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      Email: info@creative-bioarray.com
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Contact Us
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-bioarray.com

Europe
Tel: 44-207-097-1828
Email: info@creative-bioarray.com