- IL-16 is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of IL-16 is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. Major IL-16 functions are exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase-3 is reported to be involved in the proteolytic processing of this protein. Two transcript variants encoding different isoforms have been found for this gene.IL-16 stimulates a migratory response in cd4+ lymphocytes, monocytes, and eosinophils and it also induces t-lymphocyte expression of interleukin-2 receptor ligand for cd4.|Recombinant mouse IL-16 produced in E. coli is a single, non-glycosylated polypeptide chain of 127 amino acids having a molecular mass of 13.2 kDa. It has been purified by using proprietary chromatographic techniques.
- Product Overview
- Mouse Il16 expressed in E.coli
- CAT# CSC-CTK0693-10 (10 μg); CAT# CSC-CTK0693-50 (50 μg)
- Greater than 90% as determined by SDS-PAGE and RP-HPLC analysis.
- Lyophilized from a concentrated (1 mg/ml), sterile- filtered protein solution after extensive dialysis against 10 mM sodium phosphate buffer (pH 7.5).
- Please centrifuge product briefly before opening the vial. The lyophilized protein should be reconstituted in sterile, ultra-pure water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at –20°C for future use.
- Storage & Stability
- The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored dessicated at -20°C. Reconstituted protein should be used immediately or stored long-term in undiluted working aliquots at –20°C. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze / thaw cycles.
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