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ActoFactor™ Recombinant Human Tumor necrosis factor receptor superfamily, member 10b

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Cat.No.
CSC-CTK0336
Description
TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic death domain, which can activate the cells apoptotic machinery. These receptors are activated by binding to wither membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-2/DR5 is a 14.9 kDa protein (133 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.
Species
Human
Product Overview
Human TNFRSF10B expressed in E.coli
Molecular Mass
14.9 kDa
Size
CAT# CSC-CTK0336-50 (50 μg); CAT# CSC-CTK0336-250 (250 μg)
Expression System
E.coli
Purity
Greater than 98% as determined by SDS-PAGE and HPLC analysis.
Activity
Determined by its inhibitory effect of IL-8 production in human PBMC by human sTRAIL/Apo2L. 50% inhibition (100 ng/ml of s TRAIL/Apo2L) was reached using a concentration of 1000 ng/ml of sTRAIL Receptor-2.
Endotoxin Level
Less than 1 EU/μg.
Formulation
The sterile-filtered solution was lyophilized with no additives.
Reconstitution
Please centrifuge product briefly before opening the vial. Reconstitute in sterile, ultra-pure water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted into other aqueous buffers and stored at -20°C for future use.
Storage & Stability
The lyophilized powder, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted sTRAIL Receptor-2 should be used immediately or stored in undiluted working aliquots at -20°C. Avoid repeated freeze / thaw cycles.
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

For research use only. Not for any other purpose.

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