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ActoFactor™ Recombinant Human Tumor necrosis factor receptor superfamily, member 10a
- Specification
- Recommended Products
Cat.No.
CSC-CTK0335
Description
TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic death domain, which can activate the cells apoptotic machinery. These receptors are activated by binding to wither membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-1/DR4 is a 22.7 kDa protein (216 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.
Species
Human
Product Overview
Human TNFRSF10A expressed in E.coli
Molecular Mass
22.7 kDa
Size
CAT# CSC-CTK0335-50 (50 μg); CAT# CSC-CTK0335-250 (250 μg)
Expression System
E.coli
Purity
Greater than 98% as determined by SDS-PAGE and HPLC analysis.
Activity
Measured by its ability to inhibit apoptosis in LN-18 cells. The expected ED50 for this effect is 0.4 -0.5 μg/ml.
Endotoxin Level
Less than 1 EU/μg.
Formulation
The sterile-filtered solution was lyophilized with no additives.
Reconstitution
Please centrifuge product briefly before opening the vial. Reconstitute in sterile, ultra-pure water to a concentration of 0.1 - 1.0 mg/ml. This solution can be diluted into other aqueous buffers and stored at -20°C for future use.
Storage & Stability
The lyophilized powder, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted sTRAIL Receptor-1 should be used immediately or stored in undiluted working aliquots at -20°C. Avoid repeated freeze / thaw cycles.
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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