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ActoFactor™ Recombinant Human Transforming growth factor, beta receptor II (70/80kDa)

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  • Specification
  • Recommended Products
  • Cat.No.
  • CSC-CTK0333
  • Description
  • TGFBR2 is part of the Ser/Thr protein kinase family and the TGFB receptor subfamily. TGFBR2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 expression is increased in oral squamous cell carcinoma cells. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity of tamoxifen metabolites in breast cancer. Human Recombinant TGFBR2 produced in E. coli is a single, non-glycosylated, polypeptide chain encoding 133 amino acids (4-136 aa, the extracellular domain of TGFBR2) with a molecular mass of 15.1 kDa.
  • Species
  • Human
  • Product Overview
  • Human TGFBR2 expressed in E.coli
  • Molecular Mass
  • 15.1 kDa
  • Size
  • CAT# CSC-CTK0333-10 (10 μg); CAT# CSC-CTK0333-50 (50 μg)
  • Expression System
  • E.coli
  • Purity
  • Greater than 97% as determined by SDS-PAGE analysis.
  • Activity
  • Measured by its ability to inhibit TGF-b1 activity on a mouse T cell line, HT-2.
  • Endotoxin Level
  • N/A
  • Formulation
  • Lyophilized from a sterile-filtered solution in buffer containing 150 mM NaCl and 50 mM sodium phosphate buffer (pH 7.5).
  • Reconstitution
  • Please centrifuge product briefly before opening vial. The lyophilized protein should be reconstituted in sterile, ultra-pure water to a concentration of 0,1 - 1,0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.
  • Storage & Stability
  • The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted rRa Leptin should be used immediately or stored long-term in undiluted working aliquots at -20°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.

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    • USA
      45-1 Ramsey Road, Shirley, NY 11967, USA
      Tel: 1-631-626-9181
      Fax: 1-631-614-7828
      Email: info@creative-bioarray.com
      Europe
      Tel: 44-207-097-1828
      Email: info@creative-bioarray.com
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Contact Us
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-bioarray.com

Europe
Tel: 44-207-097-1828
Email: info@creative-bioarray.com