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ActoFactor™ Recombinant Human Prolactin

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  • Specification
  • Recommended Products
  • Cat.No.
  • CSC-CTK0060
  • Description
  • Prolactin (PRL) is a neuroendocrine pituitary hormone. PRL is synthesized by the anterior pituitary, placenta, brain, uterus, dermal fibroblasts, decidua, B cells, T cells, NK cells and breast cancer cells. PRL is a lactogenic hormone, also involved in breast cancer development , regulation of reproductive function, and immunoregulation. In the immune system, PRL has been shown to be secreted by human PBMC and to act as a proliferative growth factor and an IFN-g inducer. The mature protein containing 200 amino acid residues migrates with an apparent Mr of 23 kDa. PRL binds to a class I cytokine receptor. Prolactin signal transduction involves the JAK/STAT families and Src kinase family.
  • Species
  • Human
  • Product Overview
  • Human PRL expressed in E.coli
  • Sequence
  • A DNA sequence encoding the mature human prolactin protein sequence (aa residues 29 - 227) was expressed in E. coli.
  • Size
  • CAT# CSC-CTK0060-50 (50 μg); CAT# CSC-CTK0060-250 (250 μg)
  • Expression System
  • E.coli
  • Purity
  • Greater than 97% as determined by SDS-PAGE and visualized by silver stain
  • Activity
  • Activity was determined in a cell proliferation assay using the rat lymphoma, Nb2-11 and the ED50 for this effect was typically 0.03 - 0.1 ng/mL.
  • Endotoxin Level
  • Endotoxin level less than 0.1 ng per 1mg of the cytokine as determined by the LAL method.
  • Formulation
  • Lyophilized from a 0.2 μm filtered solution in 30% CH3CN, 0.1% TFA.
  • Reconstitution
  • It is recommended that sterile PBS containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of no less than 10 mg/mL.
  • Storage & Stability
  • Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted PRL can be stored under sterile conditions at 2°C to 4°C for one month or at -20°C to -70°C for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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    • USA
      45-1 Ramsey Road, Shirley, NY 11967, USA
      Tel: 1-631-626-9181
      Fax: 1-631-614-7828
      Email: info@creative-bioarray.com
      Europe
      Tel: 44-207-097-1828
      Email: info@creative-bioarray.com
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Contact Us
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-bioarray.com

Europe
Tel: 44-207-097-1828
Email: info@creative-bioarray.com