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ActoFactor™ Recombinant Human Interleukin 4 receptor

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  • Specification
  • Recommended Products
  • Cat.No.
  • CSC-CTK0225
  • Description
  • IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain. The type I receptor contains in addition to the gamma chain an IL-4R alpha subunit, whereas the type II receptor contains the IL-13R alpha. The secreted extracellular domain of IL- 4R alpha, called sIL-4R alpha, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naive CD4+ T cells and class switching to IgG1 and IgE. Recombinant human sIL-4R alpha is a 207 amino acid protein which corresponds to the entire extracellular domain of IL-4R alpha.
  • Species
  • Human
  • Product Overview
  • Human IL4R expressed in HEK293 cells
  • Molecular Mass
  • 23.7 kDa
  • Size
  • CAT# CSC-CTK0225-15 (15 μg); CAT# CSC-CTK0225-75 (75 μg)
  • Expression System
  • HEK293 cells
  • Purity
  • Greater than 97% as determined by SDS-PAGE and HPLC analysis.
  • Activity
  • The ED50 was determined by its ability to inhibit the IL-4 dependent proliferation of human TF-1 cells and is 2 x 10^5 units/mg.
  • Endotoxin Level
  • Less than 1 EU/μg.
  • Formulation
  • Recombinant human sIL-4 Receptor was lyophilized from a sterile-filtered solution with no additives.
  • Reconstitution
  • Please centrifuge product before briefly opening vial. The lyophilized protein should be reconstituted in sterile, ultra-pure water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.
  • Storage & Stability
  • The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted rHu sIL-4 Receptor should be used immediately or stored long-term in undiluted working aliquots at -20°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.

Citation Guidance:
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon.

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    • USA
      45-1 Ramsey Road, Shirley, NY 11967, USA
      Tel: 1-631-626-9181
      Fax: 1-631-614-7828
      Email: info@creative-bioarray.com
      Europe
      Tel: 44-207-097-1828
      Email: info@creative-bioarray.com
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Contact Us
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-bioarray.com

Europe
Tel: 44-207-097-1828
Email: info@creative-bioarray.com