- The IL-1RL1 gene is a member of the IL-1 receptor family, encoding a transmembrane protein with a structure similar to IL-1R1. IL-1RL1 is a receptor for Interleukin-33, its stimulation recruits MYD88, IRAK-1, IRAK-4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL-1RL1 may possibly be involved in helper T-cell function. IL-1RL1 is highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. A soluble form of the IL-1RL1 is produced from the same gene by alternative splicing and was shown to be expressed in several cell types including fibroblasts and mast cells. Soluble IL-1RL1 also acts as a negative regulator of Th2 cytokine production and high levels have been reported in several disease states and conditions including asthma, sepsis and myocardial infarction. Analysis of the similar gene in mouse suggested that the IL-1RL1 receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. Human recombinant IL-1RL1 produced in E. coli is a single, non-glycosylated, polypeptide chain containing 310 amino acids fragment (19-328) corresponding to the soluble IL-1RL1 coding sequence, having a molecular weight of 36 kDa and fused with a 4.5 kDa amino-terminal hexahistidine tag.
- Product Overview
- Human IL1RL1 expressed in E.coli
- CAT# CSC-CTK0215-10 (10 μg); CAT# CSC-CTK0215-50 (50 μg)
- Greater than 95% as determined by SDS-PAGE analysis.
- Sterile-filtered, colorless clear solution in 1X PBS, 50% glycerol.
- Please centrifuge product briefly before opening vial. The dissolved protein can be diluted into other aqueous buffers and stored at -20°C for future use.
- Storage & Stability
- Store at 4°C if entire vial will be used within 4 weeks. Store frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
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