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ActoFactor™ Recombinant Human Growth & Differentiation Factor 8 (Myostatin Propeptide)
- Specification
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Cat.No.
CSC-CTK0542
Description
Myostatin (GDF-8), a member of the TGF-beta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The myostatin propeptide is a negative regulator of myostatin in vivo. 28 kDa protein containing 243 amino acid residues of the human Myostatin Propeptide and 5 additional amino acid residues.
Species
Human
Product Overview
Human GDF8 expressed in E.coli
Molecular Mass
28 kDa
Size
CAT# CSC-CTK0542-25 (25 μg); CAT# CSC-CTK0542-125 (125 μg)
Expression System
E.coli
Purity
Greater than 95% as determined by HPLC and SDS-PAGE analysis.
Activity
N/A
Endotoxin Level
N/A
Formulation
Sterile-filtered, white, lyophilized (freeze-dried) powder. Lyophilized from a concentrated (1 mg/ml) solution containing 10 mM acetic acid.
Reconstitution
Please centrifuge product briefly before opening vial. The lyophilized protein should be reconstituted in sterile, ultra-pure water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.
Storage & Stability
The lyophilized protein, is best stored desiccated at -20°C. Reconstituted rHu GDF-8 should be used immediately or stored long-term in undiluted working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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