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ActoFactor™ Recombinant Human CD22 molecule
- Specification
- Recommended Products
Cat.No.
CSC-CTK0288
Description
CD22 is a 135 kDa B-cell restricted sialoglycoprotein that binds to oligosaccharides containing 2- 6-linked sialic acid residues. It is present in the cytoplasm of nearly all B-lineage cells and is also expressed on the surface of B-cells during advance stages of differentiation. Although the exact physiological function of CD22 is unclear, it appears to play a role in B-cell activation and to act as an adhesion molecule. The potential therapeutic use of CD22 and anti-CD22 may be useful in diagnostic and/or treatment of leukemia, lymphoma, non-Hodgkins lymphoma and certain autoimmune conditions. (Cesano A. and Gayko U. Semin. Oncol. Apr. 2003 (2): 253-257). Recombinant human CD22 is a soluble 75.0 kDa (666 amino acid residues) protein which corresponds to the extracellular domain of CD22.
Species
Human
Product Overview
Human CD22 expressed in CHO cells
Molecular Mass
75 kDa
Size
CAT# CSC-CTK0288-10 (10 μg); CAT# CSC-CTK0288-50 (50 μg)
Expression System
CHO cells
Purity
Greater than 98% as determined by SDS-PAGE and HPLC analysis.
Activity
Determined by its ability to inhibit proliferation of Raji cells. The expected ED50 for this effect is 10-17 μg/ml.
Endotoxin Level
Less than 1 EU/μg.
Formulation
Lyophilized (freeze-dried), sterile powder. Lyophilized with no additives.
Reconstitution
Please centrifuge product briefly before opening vial. The lyophilized protein should be reconstituted in sterile, ultra-pure water to a concentration of 0,1 - 1,0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.
Storage & Stability
The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted rHu CD22 should be used immediately or stored long-term in undiluted working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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