- BMP-5 belongs to the bone morphogenetic protein family which is part of the transforming Growth Factor-beta superfamily. This superfamily is comprised of large families of growth and differentiation factors. Bone morphogenetic proteins were initially identified by their ability of demineralizing bone extract to induce endochondral osteogenesis in vivo in an extra-skeletal site. BMP-5 is an essential signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. It was shown that BMP-5 increases the levels of osteopontin, BMP-2, alkaline phosphatase and core binding factor alpha 1 mRNAs in human periodontal (HPL) ligament cells. The BMP-5 protein is expressed in normal synovial tissue and reduced in osteoarthritis and rheumatoid arthritis. BMP-5 may have a role in certain cancers given that it is differentially regulated during the formation of different tumors. Human recombinant BMP-5 produced in E. coli is a single, non-glycosylated, polypeptide chain containing 139 amino acids (317-454 a.a.) and having a total molecular mass of 15.7 kDa.
- Product Overview
- Human BMP5 expressed in E.coli
- CAT# CSC-CTK0530-20 (20 μg); CAT# CSC-CTK0530-100 (100 μg)
- Greater than 95% as determined by SDS-PAGE analysis.
- Sterile-filtered, colorless protein solution in 10 mM sodium citrate buffer (pH 3.5) and 10% glycerol.
- Please centrifuge product briefly before opening vial. The dissolved protein can be diluted into other aqueous buffers and stored at -20°C for future use.
- Storage & Stability
- Store at 4°C if entire vial will be used within 4 week. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
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