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ActoFactor™ Recombinant Human Bone Morphogenetic Protein 14 (CDMP-1)

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  • Specification
  • Recommended Products
  • Cat.No.
  • CSC-CTK0546
  • Description
  • BMP-14 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the BMP-14 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities, and in Hunter- Thompson type dwarfism. The mature and functional form of BMP-14 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each BMP-14 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino-acid signal peptide and a 354 amino-acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant human BMP-14 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids.
  • Species
  • Human
  • Product Overview
  • Human GDF5 expressed in E.coli
  • Molecular Mass
  • 27.0 kDa
  • Size
  • CAT# CSC-CTK0546-50 (50 μg); CAT# CSC-CTK0546-250 (250 μg)
  • Expression System
  • E.coli
  • Purity
  • Greater than 98% as determined by SDS-PAGE and HPLC analysis.
  • Activity
  • The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1.0-2.0 μg/ml.
  • Endotoxin Level
  • Less than 1 EU/μg.
  • Formulation
  • Lyophilized from a sterile-filtered solution with no additives.
  • Reconstitution
  • Please centrifuge product before opening vial. The lyophilized protein should be reconstituted with distilled, sterile water to a concentration of 0.1-1.0 mg/ml. For further dilution, carrier protein (0.1% BSA or HSA) should be added to avoid loss of bioactivity.
  • Storage & Stability
  • The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted protein should be used immediately or stored long-term in undiluted working aliquots at -20°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.

Citation Guidance:
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon.

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    • USA
      45-1 Ramsey Road, Shirley, NY 11967, USA
      Tel: 1-631-626-9181
      Fax: 1-631-614-7828
      Email: info@creative-bioarray.com
      Europe
      Tel: 44-207-097-1828
      Email: info@creative-bioarray.com
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Contact Us
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-bioarray.com

Europe
Tel: 44-207-097-1828
Email: info@creative-bioarray.com